Pharmaceutical Applications of Micromeritics

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In pharmacy, micromeritics is employed for:

Release and Dissolution: Clinically, the particle size and surface area of a drug can affect its release from dosage forms administered orally, parenterally, rectally, and topically. Finely powdered drug has a high surface area, hence gets easily dissolved in dissolution fluids in vivo, thereby enhancing the drug solubility and dissolution.

Absorption and Drug Action: Drug absorption and its pharmacological response are affected by the size and surface area of particle. Higher the dissolution rate, faster the absorption rate, hence quicker and greater the drug action.

Physical Stability: The physical stability of some pharmaceutical preparations, like suspensions and emulsions are affected by the particle size. Depending upon the particle size, the physical stability of the drug also changes; smaller the size of particles, greater will be the physical stability of the drug owing to the Brownian movement of the particles in the dispersion.

Dose Uniformity: Good flow properties of granules and powders are required for formulating tablets and capsules. In terms of weight and number, the particles should be uniformly distributed throughout the drug.

Read More Topics
Method for determining particle volume
Rheological properties of emulsions
Emulsion formulation by HLB method

Santhakumar Raja

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