Amnio alcohol esters a.clidinium bromide ( cinipox) 3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide Mechanism of Action: It inhibits muscarinic actions of acetylcholine at postganglionic...
Tag - Health Science
Sympathomimetic drugs stimulate the sympathetic or adrenergic nerve, directly by mimicking the action of NE or indirectly by stimulating the release of NE. STRUCTURE ACTIVITY RELATIONSHIP The sympathomimetic drugs may be...
Cholinergic neurons contain a large number of small membrane bound vesicle containing Ach near the synaptic portion of cell membrane. Ach is synthesized in the cytoplasm from acetyl-CoA and choline by the catalytic action of...
Cholinergic drugs or Cholinomietics or Parasympathomietics are drugs producing action similar to acetylcholine by interacting with cholinergic receptor or increasing the availability of acetylcholine at these sites. These agents...
Cholinergic blocking agents are also known as antimuscarinic, anticholinergic, parasympatholytic or cholinolytic drugs. Antimuscarinic drug are those which antagonises the effect of Acetylcholine by binding to muscarinic...
Morphine is one of the most abundant opioid found in opium. It is regarded as the gold standard or benchmark of analgesic used to relieve intense pain. Morphine is named after the Roman god of sleep Morpheus. It is an alkaloid...
In biphenyl (I) two phenyl groups are linked by a single bond (sp2 -sp2), known as pivotal bond. The distance between ortho H‘s in adjacent rings in the planar conformation is significantly greater (0.29nm) than twice the...
A classic example of ring versus non-cyclic structure is Diethyl stilboestrol and 17β-oestradiol. The molecular design of Diethylstilboestrol was carried out by opening the B and C of steroidal nucleus of oestradiol. Due to...
a. Replacement of Fluorine atoms for Hydrogen Fluorine is most commonly employed as monovalent bioisosteric replacement for hydrogen. Stearic parameter for hydrogen and fluorine are similar, their Vander waal’s radii being...
Phase I Reaction (I) Oxidative Reactions (i) Oxidation of aromatic moieties (ii) Oxidation of Olefins (iii) Oxidation at benzylic, allylic carbon atoms and carbon atoms α to carbonyl and imines (iv) Oxidation at aliphatic and...
