Myasthenia Gravis (MG) is an autoimmune disorder, in which antibodies are produced at neuromuscular junction (NMJ) against the NM receptors, so, it results in decrease in the number of NM receptors. Patients with myasthenia...
Category - Health Science
Neurohumoral transmission involves the following four steps (figure) Step 1: Initiation of an Action Potential and Axonal Conduction During resting conditions, the membrane potential inside a typical axon is −70mV with...
Autonomic Nervous System has the following functions : Reflex Activities : The ANS is involved in complex reflex activities that depend on sensory input to the CNS and on motor output. Reflex actions are rapid and are coordinated...
The differences between sympathetic and parasympathetic nervous system according to their origin, character and effect on respective organs are listed in table. Sympathetic Parasympathetic Origin From all thoracic and...
The preganglionic fibres of the parasympathetic nervous system arise from the cell bodies of the CNS. The preganglionic fibres originate from the nuclei of the third, seventh, ninth and tenth cranial nerves (CN III, VII, IX, and...
The preganglionic fibres of the sympathetic nervous system arise from the cell bodies spanning from the Thoracic (T1) to the Lumbar (L2) part of the spinal cord. The Sympathetic Nervous System is made up of the following...
These receptors possess a subunit along with enzymatic property or bind a JAK (Janus Kinase) enzyme on activation. The outer face of plasma membrane carry binding site for agonist and the inner face has catalytic site (figure). A...
These receptors belong to a large family of cell membrane receptors. These receptors are bonded with effector (enzyme/channel/carrier protein) by one or more GTO-activated protein (G-protein) to give effective response. The...
The drug receptor interaction may be affected by : Isosterism : Isosteres are groups of atoms having identical physical or chemical properties of a molecule due to resemblance in size, electronegativity, or stereochemistry, and...
In molecular terms, the activity of drugs is initiated by their atomic level interaction with a receptor. Since the association of small molecules (e.g., drugs) with macromolecules (e.g., receptors) is promoted and stabilised by...
