Introduction Various techniques are available for enhancing the solubility of poorly soluble drugs. Some of these approaches are as follows: Chemical Modifications: i) Use of salt forms ii) Co-crystallisation iii)...
Category - Health Science
Factors affecting protein-drug binding are categorised as follows: Drug-Related Factors i) Physicochemical characteristics of drug, ii) Concentration of drug in body, and iii) Affinity of a drug for a particular binding...
Protein-drug binding has the following clinical applications: In a few cases, drug-protein interaction may cause a prolonged residence of drug in the body. Plasma proteins are not a normal component of the glomerular filtrate...
The ancient folk medicine and early natural-product emerged the field of medicinal 1 chemistry about 150 years ago. The oldest record ( 5100 years ago) of the use of medicinal plants are from the ancient civilization of the...
Metabolism of drugs involves many important enzymes and pathways. Based on the type of reaction catalysed by them, they can be categorised as: Enzymes involved in Phase I Metabolism include: i) In Oxidation: Cytochrome P-450...
Different types of barriers are found in the body that restrict the distribution of various compounds that enter the blood to different tissues. These barriers are present in the body for protecting the sensitive tissues from the...
If the blood flows rapidly and uniformly to the entire body tissues, differences in the degree of distribution between tissues will indicate the differences in the tissue penetrability of the drug. Thıs process will be tissue...
Drugs are most often administered extravascularly and are mainly intended to produce systemic action; for this reason, absorption is a prerequisite for pharmacological effects. Delays or drug loss during absorption contribute to...
Medicinal and Pharmaceutical Chemistry is a chemistry-based scientific discipline, with an interaction of chemistry and pharmacology. Medicinal Chemistry also involves the aspects of biological, medical and pharmaceutical...
On the basis of size of heterocyclic rings, classification of these compounds is done into following types: Five-Membered Heterocyclic Compounds: These are five membered ring compounds consisting of one hetero atom and four...
