Drugs can bind either through plasma proteins or blood cells : Binding of Drugs to Plasma Proteins : In systemic circulation drug interacts with plasma and blood components (plasma proteins, blood cells and haemoglobin). In blood compartment, drugs mainly interact with plasma which is found abundantly. Plasma protein reversibly binds to blood. Order of binding
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Drugs distribution is affected by : Age : Distribution varies with difference in : Total Body Content (Intracellular and Extracellular) : It is maximum in infants. Fat Content : Greater in infants and in elder ones. Skeletal Muscles : Less in infants and elderly people. Organic Composition : Poorly developed BBB, low myelin content and
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A number of drugs are yielded by plants and animals. This classification can be done according to the physical and chemical properties of the drug. In this, drugs are categorised in the following groups: Alkaloids : Compounds made up of carbon, hydrogen, nitrogen and oxygen are known as alkaloids (alkali-like). They are administered in small
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The following points help to understand the nature of drugs in a better manner: Physical State of Drug : At room temperature, drugs may either be in the form of solid (e.g., aspirin, atropine), liquids (e.g., nicotine, ethanol), or gases (e.g., nitrous oxide). The route which is the best for its administration is often determined
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Introduction of Drugs In general, any substance which brings about a change in the biological functions by way of its chemical action is defined as a drug. Drug may be a therapeutic agent which is used in the prevention, diagnosis, treatment, control or cure of the infectious and diseased conditions. The term drug is originated
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