These receptors belong to a large family of cell membrane receptors. These receptors are bonded with effector (enzyme/channel/carrier protein) by one or more GTO-activated protein (G-protein) to give effective response. The structural organisation of all such receptors is common. GTP carrying α-subunit dissociated from the other two subunits can either inhibit or activate the effector. The β and γ
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The drug receptor interaction may be affected by : Isosterism : Isosteres are groups of atoms having identical physical or chemical properties of a molecule due to resemblance in size, electronegativity, or stereochemistry, and presence of these groups in molecules is known as isosterism. For example, N2 and CO, both have 14 total electrons and no charges
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In molecular terms, the activity of drugs is initiated by their atomic level interaction with a receptor. Since the association of small molecules (e.g., drugs) with macromolecules (e.g., receptors) is promoted and stabilised by intermolecular interactions, an understanding of the nature of chemical bonds and intermolecular interactions is of great interest to the medicinal chemist.
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