September 9, 2023

Two important interfacial properties of suspensions are: The surface free energy, and The presence of electric charges on the surface of the dispersed particles. Surface Free Energy When solid or liquid materials are reduced in size, the surface area increases readily leading to corresponding increase in surface free energy given by: ΔF ∝ ΔA ΔA

Flocculated and deflocculated suspension: The solid drug is crushed into smaller particles and then dispersed in a dispersion medium in order to prepare a suspension. As a result of crushing, the surface area of particles and their associated surface free energy increases. This makes the system thermodynamically unstable with highly energetic particles which regroup and